CBI is a TLA with a number of meanings, including:

* Caribbean Basin Initiative
* Center for the Promotion of Imports, CBI, The Netherlands,
* Center for Biomedical Imaging, Boston MA.
* Central Bank of India
* Central Bank of Iran
* Central Bureau of Investigation, India
* Central Bank of Ireland
* Charles Babbage Institute
* China Burma India theater of World War II
* College Bowl Incorporated
* Confederation of British Industry
* Cosmic Background Imager
* CBI and CBI-FM, radio stations in Sydney, Nova Scotia, Canada
* Cheney Brothers Inc.
* Clear Barrel Indicator
* Chicago Bridge and Iron
* Computer-Based Instruction
* Cycle Banditos Illegal - a non-official, underground bicycle messenger squad in Budapest, Hungary
* China Biodiesel International